Featured Research Program
Study: Investigating the role of Glut1 in the microvascular complications of diabetes
PI: Ivy Samuels, Ph.D.
Nearly 25% of veterans are affected by diabetes. Diabetic microvascular complications occur in up to 60% of diabetic patients, significantly reducing quality of life and increasing mortality. Diabetic Retinopathy is the leading cause of blindness, Diabetic Kidney Disease is the leading cause of end-stage renal disease and Diabetic Peripheral Neuropathy is the leading cause of non-traumatic lower extremity amputation. However, few effective therapies to slow or prevent the development of each disorder are currently prescribed. While each comorbidity develops independently, hyperglycemia is a major risk factor for all, and intensive glycemic control mitigates their severities. Because glucose levels in the eye, kidney and peripheral nerves approximate blood glucose levels, systemic hyperglycemia leads to chronic oxidative stress, inflammation and damage in each tissue. This damage in turn compromises microvascular function and drives diabetic eye, kidney and peripheral nerve pathology. Therefore, it is important to identify ways to prevent these complications.
Our research aims to determine (1) whether systemic reduction of the facilitative glucose transporter, Glut1, prevents these complications by lowering glucose levels in each tissue, and (2) to elucidate molecular mechanisms that regulate Glut1 in each tissue. Our goal is to determine whether reduced glucose transport via Glut1 is effective in preventing onset of each of the microvascular complications of diabetes and to identify novel therapeutic targets for reduction of glucose transport into compromised tissues.
National VA Research Week 2024
Thank you to all who presented and attended Research Day this year at the Cleveland VA. It was a fantastic opportunity to learn about the incredible research that is being conducted here at the Cleveland VA. We eagerly anticipate 2025. If you have any suggestions on how we can enhance next year's event, please share your ideas with Candice Toney at candice.toney@va.gov. Your input is important to us!
|
Research Forums
Research forums will be held monthly. Our spring/summer schedule is listed below. Presentations will be broadcast using MS Teams.
Tuesday, June 25 @ 1:00PM
Research Compliance Overview, presented by, Jennifer Zindle, Research Compliance Officer
Microsoft Teams meeting; Join on your computer, mobile app or room device
Meeting ID: 274 189 817 615 Passcode: qFJwSr
Click here to join the meeting
Tuesday, July 23 @ 1:00PM
Privacy Overview, presented by, Joe Picklo, Privacy Officer
Compliance Office Tip of the Month:
When consenting a subject, remember to always thoroughly check the documents for completeness and accuracy – before the subject leaves the room! This helps ensure you’ve covered everything, helps to check again that the subject has understood everything presented to them, and it gives you an opportunity to catch mistakes while they are still easily fixable! Come prepared to consenting appointments with pens that work well and a checklist to help yourself remember all aspects of the consenting process. Finally, don’t forget to provide the subject a complete copy of all consenting documents that they sign.
Office Hours (Research Compliance & Education)
Research Compliance Office & Research Service (Education) have an open forum via teams the 2nd & 4th Wednesday of each month from 12:30pm-1:00pm. NOTE the new time.
During the office hours you can ask any questions that you may have about Research Compliance/Research Education.
If you have topics that you would like us to discuss in future office hours, please send an email to Jennifer Zindle jennifer.zindle@va.gov
Please use the link below to join us on Wednesday, June 19, 2024
Join on your computer, mobile app or room device
Click here to join the meeting
Meeting ID: 236 321 831 958 Passcode: HAvGVK
GRECC Statistical Resource Center (SRC)
The GRECC SRC team is a valuable resource for researchers, offering a range of services to support and advance your research endeavors.
Here are some of the services provided by the SRC:
- Study design
- Assistance with IRB study submission (analytic plan only)
- Support with grant preparation (analytic plan only)
- Guidance on planning data acquisition -
- DSMB reports
- Data analysis
- Data visualization
- Help with methods documentation in manuscripts/presentations
Researchers can reach out to the GRECC SRC team for assistance with statistical inquiries, study planning, or data analysis. No funding is required to access their services.
VA network access is needed to visit the SharePoint site for more information:
GRECC SRC Sharepoint
Study Initiation Visits
What is a Study Initiation Visit?
The study initiation visit encompasses a review of regulatory requirements as they apply to your specific study, good clinical practice guidelines, the informed consent and HIPAA documents as well as a review of how to maintain study records (regulatory binder and subject files).
The Research Compliance Office is required to perform a triennial regulatory audit of studies (human subjects' research, animal protocols, and basic science studies) and informed consent and HIPAA audits if applicable. The intent of a study initiation visit is to help the researcher avoid the most common audit findings before they occur.
Did you know that you can schedule a Study Initiation Visit with the Research Service?
The study initiation visit is available to all research staff. If you are new to research or need a refresher, you can schedule a study initiation visit today.
For scheduling or questions contact Candice Toney at Candice.Toney@va.gov or 216-791-3800 x66785.
Upcoming VA Research Funding Deadlines
The next round of BLR&D and CSR&D VA Grant Applications will be submitted in September.
Please contact Christine.Hendricks@va.gov if you are planning to submit or have any questions.
Office of Research & Development
Upcoming Webinars: ePROS Webinars (va.gov)
06/18/2024- Implementation of VHA Directive 1200.13: Financial Conflicts of Interest and Interest and Outside Compensation for Performance in VA Research (May 2, 2024);Click here to join the meeting
Archived webinars can be found at:ePROS Webinars (va.gov)
Recent webinars:
(05/28/2024) VAIRRS Data Webinar Series: Introduction to the VAIRRS Data Integrity Initiative
(05/15/2024) New Financial Management Expectations for FY 25
(04/19/2024) National Cancer Institute (NCI) Cancer Trials Support Unit (CTSU) Website Training
VIREC Good Data Practices (GDP) Webinars
05/29/2024 Notes to Your Future Self: The Living Protocol registration - VA WebEx Enterprise Site
Stay Connected
VA Northeast Ohio Healthcare System
Cleveland Research Website
Office of Research & Development
|
