April 2021 Research Notables

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Dear Colleagues,

I am sure everyone is looking forward to spring and summer! Congratulations to the recent grant recipients and our VA Investigators’ recent accomplishments.

Over the course of next few months, we are hoping to transition to a new electronic system, VA Innovation and Research Review System (VAIRRS). We will be using VAIRRS  for management and review of  research protocols and will replace iMEdRIS. We will be hosting several training sessions to get everyone up to speed before and during this transition. 

We will also be celebrating National VA Research Week on May 17-21. National VA Research Week is a time to mark the achievements and innovations of the nationwide VA research enterprise and community and to acknowledge the valued partners that  help us achieve our mission on behalf of Veterans. Our 2021 Research Week theme is VA Research: One Team, One Mission. 

Please save the date, Thursday, May 20 at 11:00 AM for our Keynote event featuring William Curt LaFrance, MD, MPH. Due to COVID-19, this will take place via Webex. Please check your inboxes over the next few weeks for more details.  


Sincerely,

Gaurav Choudhary, MD
Associate Chief of Staff (Research)
https://twitter.com/GChoudharyMD


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Grants and Awards

Kevin McConeghy, Pharm.D., was awarded $29,997 over 6 months from the Brown University P01 Award for "Temperature Screening and SARS-COV-2 In Nursing Home Residents with Dementia"

Whitney Mills, PhD, was awarded $280,700 over 4 years from the Health Services Research & Development for "Montessori Approaches in Person-Centered Care (MAP-VA): An Effectiveness-Implementation Trial in Community Living Centers"


Publications (Since February 5th, 2021)

Anderson MC, Evans E, Zonfrillo MR, Thomas KS. Rural/urban differences in discharge from rehabilitation in older adults with traumatic brain injury. J Am Geriatr Soc. 2021 Mar 6. doi: 10.1111/jgs.17065. Epub ahead of print. PMID: 33675540.

Appaneal HJ, Caffrey AR, Lopes VV, Mor V, Dosa DM, LaPlante KL, Shireman TI. Predictors of potentially suboptimal treatment of urinary tract infections in long-term care facilities. J Hosp Infect. 2021 Feb 5;110:114-121. doi: 10.1016/j.jhin.2021.01.019. Epub ahead of print. PMID: 33549769.

Bardenheier BH, Wu WC, Zullo AR, Gravenstein S, Gregg EW. Progression to diabetes by baseline glycemic status among middle-aged and older adults in the United States, 2006-2014. Diabetes Res Clin Pract. 2021 Mar 1;174:108726. doi: 10.1016/j.diabres.2021.108726. Epub ahead of print. PMID: 33662490.

Barie PS, Ho VP, Hunter CJ, Kaufman EJ, Narayan M, Pieracci FM, Schubl SD, Heffernan DS, Huston JM. Surgical Infection Society Guidance for Restoration of Surgical Services during the Coronavirus Disease-2019 Pandemic. Surg Infect (Larchmt). 2021 Feb 25. doi: 10.1089/sur.2020.421. Epub ahead of print. PMID: 33635145.

Barredo J, Berlow Y, Swearingen HR, Greenberg BD, Carpenter LL, Philip NS. Multimodal Elements of Suicidality Reduction After Transcranial Magnetic Stimulation. Neuromodulation. 2021 Mar 1. doi: 10.1111/ner.13376. Epub ahead of print. PMID: 33650209.

Beganovic M, Daffinee KE, Luther MK, LaPlante KL. Minocycline Alone and in Combination with Polymyxin B, Meropenem, and Sulbactam against Carbapenem-Susceptible and -Resistant Acinetobacter baumannii in an In Vitro Pharmacodynamic Model. Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01680-20. doi: 10.1128/AAC.01680-20. PMID: 33318006.

Cosmo C, Zandvakili A, Petrosino NJ, Berlow YA, Philip NS. Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: Recent Critical Advances in Patient Care.  Curr Treat Options Psychiatry. 2021 Mar 11:1-17. doi: 10.1007/s40501-021-00238-y. Online ahead of print. PMID: 33723500 Free PMC article. Review.

Creech SK, Pulverman CS, Shin ME, Roe KT, Tzilos Wernette G, Orchowski LM, Kahler CW, Shea MT, Zlotnick C. An Open Trial to Test Participant Satisfaction With and Feasibility of a Computerized Intervention for Women Veterans With Sexual Trauma Histories Seeking Primary Care Treatment. Violence Against Women. 2021 Mar;27(3-4):597-614. doi: 10.1177/1077801219895102. Epub 2020 Jan 3. PMID: 31896315.

D'Andrea E, Vinals L, Patorno E, Franklin JM, Bennett D, Largent JA, Moga DC, Yuan H, Wen X, Zullo AR, Debray TPA, Sarri G. How well can we assess the validity of non-randomised studies of medications? A systematic review of assessment tools. BMJ Open. 2021 Mar 24;11(3):e043961. doi: 10.1136/bmjopen-2020-043961. PMID: 33762237.

De Marchis EH, Ettinger de Cuba SA, Chang L, Sheward RS, Doran KM, Gottlieb LM, Cohen AJ, Fleegler EW, Sandel MT. Screening Discordance and Characteristics of Patients With Housing-Related Social Risks. Am J Prev Med. 2021 Mar 27:S0749-3797(21)00127-6. doi: 10.1016/j.amepre.2021.01.027. Epub ahead of print. PMID: 33785274.

Deering RW, Whalen KE, Alvarez I, Daffinee K, Beganovic M, LaPlante KL, Kishore S, Zhao S, Cezairliyan B, Yu S, Rosario M, Mincer TJ, Rowley DC. Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii. J Antibiot (Tokyo). 2021 Feb 12:1–11. doi: 10.1038/s41429-021-00412-7. Epub ahead of print. PMID: 33580212; PMCID: PMC7879144.

Drwal KR, Wakefield BJ, Forman DE, Wu WC, Haraldsson B, El Accaoui RN. Home-Based Cardiac Rehabilitation: EXPERIENCE FROM THE VETERANS AFFAIRS. J Cardiopulm Rehabil Prev. 2021 Mar 1;41(2):93-99. doi: 10.1097/HCR.0000000000000594. PMID: 33647921.

Dunn HK, Pearlman DN, Montgomery MC, Orchowski LM. Predictors of Sexual Intimate Partner Violence Perpetration Among Men: A Prospective Analysis. J Interpers Violence. 2021 Feb 4:886260521989735. doi: 10.1177/0886260521989735. Epub ahead of print. PMID: 33538217.

Evans E, Kosar CM, Thomas KS. Positive Beliefs and the Likelihood of Successful Community Discharge From Skilled Nursing Facilities. Arch Phys Med Rehabil. 2021 Mar;102(3):480-487. doi: 10.1016/j.apmr.2020.09.375. Epub 2020 Sep 28. PMID: 32991871.

Ghanian S, Zakka FR, Shu N, Robinson-Bostom L, Weinstock M, Vezeridis M, Walker J. Paracicatricial melanocytes as a sign of melanoma. J Cutan Pathol. 2021 Feb 6. doi: 10.1111/cup.13977. Epub ahead of print. PMID: 33547832.

Greenberg BD, Philip NS, Fortin-Ashburne K, Carpenter LL. The COBRE Center for Neuromodulation (CCN) at Butler Hospital: Clinical-Translational Research in Human Brain Stimulation. R I Med J (2013). 2021 Mar 1;104(2):30-33. PMID: 33648316.

Gutt R, Malhotra S, Hagan MP, Lee SP, Faricy-Anderson K, Kelly MD, Hoffman-Hogg L, Solanki AA, Shapiro RH, Fosmire H, Moses E, Dawson GA. Palliative Radiotherapy Within the Veterans Health Administration: Barriers to Referral and Timeliness of Treatment. JCO Oncol Pract. 2021 Mar 18:OP2000981. doi: 10.1200/OP.20.00981. Epub ahead of print. PMID: 33734865.

Kavanaugh BC, Fryc A, Temereanca S, Tirrell E, Oberman L, Carpenter LL, Spirito A. A preliminary investigation of childhood anxiety/depressive symptomatology and working memory across multiple units of analysis. Psychiatry Res. 2021 Feb 10;298:113786. doi: 10.1016/j.psychres.2021.113786. Epub ahead of print. PMID: 33636515.

Kaze AD, Santhanam P, Erqou S, Bertoni AG, Ahima RS, Echouffo-Tcheugui JB. Cardiorespiratory Fitness and Atherosclerotic Cardiovascular Outcomes by Levels of Baseline Predicted Cardiovascular Risk: The Look AHEAD Study. Am J Med. 2021 Feb 16:S0002-9343(21)00093-0. doi: 10.1016/j.amjmed.2021.01.014. Epub ahead of print. PMID: 33607087.

Keohane LM, Thomas KS, Rahman M, Trivedi AN. Mandated Copayment Reductions in Medicare Advantage: Effects on Skilled Nursing Care, Hospitalizations, and Plan Exit. Med Care. 2021 Mar 1;59(3):259-265. doi: 10.1097/MLR.0000000000001495. PMID: 33560765; PMCID: PMC7880533.

Kim D, Lee Y, Thorsness R, Nguyen KH, Swaminathan S, Rivera-Hernandez M, Trivedi AN. Racial and Ethnic Disparities in Excess Deaths Among Persons With Kidney Failure During the COVID-19 Pandemic, March-July 2020. Am J Kidney Dis. 2021 Feb 10:S0272-6386(21)00069-X. doi: 10.1053/j.ajkd.2021.02.003. Epub ahead of print. PMID: 33581164; PMCID: PMC7875714.

Kline DK, Lin DJ, Cloutier A, Sloane K, Parlman K, Ranford J, Picard-Fraser M, Fox AB, Hochberg LR, Kimberley TJ. Arm Motor Recovery After Ischemic Stroke: A Focus on Clinically Distinct Trajectory Groups. J Neurol Phys Ther. 2021 Apr 1;45(2):70-78. doi: 10.1097/NPT.0000000000000350.PMID: 33707402

Kosar CM, White EM, Feifer RA, Blackman C, Gravenstein S, Panagiotou OA, McConeghy K, Mor V. COVID-19 Mortality Rates Among Nursing Home Residents Declined From March To November 2020. Health Aff (Millwood). 2021 Mar 11:101377hlthaff202002191. doi: 10.1377/hlthaff.2020.02191. Epub ahead of print. PMID: 33705204.

Kumar RG, Zhang W, Evans E, Dams-O'Connor K, Thomas KS. Research Letter: Characterization of Older Adults Hospitalized With Traumatic Brain Injury Admitted to Long-Term Acute Care Hospitals. J Head Trauma Rehabil. 2021 Mar 22. doi: 10.1097/HTR.0000000000000685. Epub ahead of print. PMID: 33782352.

Lin DJ, Cramer SC. Principles of Neural Repair and Their Application to Stroke Recovery Trials.  Semin Neurol. 2021 Mar 4. doi: 10.1055/s-0041-1725140. Online ahead of print. PMID: 33663003

Lynch TL 4th, Kumar M, McNamara JW, Kuster DWD, Sivaguru M, Singh RR, Previs MJ, Lee KH, Kuffel G, Zilliox MJ, Lin BL, Ma W, Gibson AM, Blaxall BC, Nieman ML, Lorenz JN, Leichter DM, Leary OP, Janssen PML, de Tombe PP, Gilbert RJ, Craig R, Irving T, Warshaw DM, Sadayappan S. Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility. J Mol Cell Cardiol. 2021 Mar 26:S0022-2828(21)00066-3. doi: 10.1016/j.yjmcc.2021.03.009. Epub ahead of print. PMID: 33781820.

Madrigal C, Kim J, Jiang L, Lafo J, Bozzay M, Primack J, Correia S, Erqou S, Wu WC, Rudolph JL. Delirium and Functional Recovery in Patients Discharged to Skilled Nursing Facilities After Hospitalization for Heart Failure. JAMA Netw Open. 2021 Mar 1;4(3):e2037968. doi: 10.1001/jamanetworkopen.2020.37968. PMID: 33724390.

McGarry BE, White EM, Resnik LJ, Rahman M, Grabowski DC. Medicare's New Patient Driven Payment Model Resulted In Reductions In Therapy Staffing In Skilled Nursing Facilities.  Health Aff (Millwood). 2021 Mar;40(3):392-399. doi: 10.1377/hlthaff.2020.00824. PMID: 33646861

Meyers DJ, Rahman M, Rivera-Hernandez M, Trivedi AN, Mor V. Plan switching among Medicare Advantage beneficiaries with Alzheimer's disease and other dementias. Alzheimers Dement (N Y). 2021 Mar 23;7(1):e12150. doi: 10.1002/trc2.12150. PMID: 33778149; PMCID: PMC7987817.

Nguyen KH, Trivedi AN, Cole MB. Receipt of Social Needs Assistance and Health Center Patient Experience of Care. Am J Prev Med. 2021 Mar;60(3):e139-e147. doi: 10.1016/j.amepre.2020.08.030. Epub 2020 Dec 11. PMID: 33309453.

Nguyen T, Joe D, Shah AD. Forget the phosphorus: A case of hypervitaminosis D-induced symptomatic hypercalcemia. Clin Nephrol Case Stud. 2021 Feb 9;9:1-3. doi: 10.5414/CNCS110414. PMID: 33614397; PMCID: PMC7890937.

Orfaly VE, Berry EG, Stoos ER, Latour E, Becevic M, Black SM, Ferris LK, Geller A, Jacobe H, Nelson KC, Prasad S, Savory S, Smith EH, Swetter SM, Weinstock MA, Xu S, Leachman SA. Melanoma toolkit for early detection (MTED) for primary care providers: A pilot study. Pigment Cell Melanoma Res. 2021 Feb 26. doi: 10.1111/pcmr.12968. Epub ahead of print. PMID: 33638298.

Palmer RHC, Benca-Bachman CE, Huggett SB, Bubier JA, McGeary JE, Ramgiri N, Srijeyanthan J, Yang J, Visscher PM, Yang J, Knopik VS, Chesler EJ. Multi-omic and multi-species meta-analyses of nicotine consumption. Transl Psychiatry. 2021 Feb 4;11(1):98. doi: 10.1038/s41398-021-01231-y. PMID: 33542196; PMCID: PMC7862377.

Panagiotou OA, Keeney T, Ogarek JA, Wulff-Burchfield E, Olszewski AJ, Bélanger E. Prevalence of functional limitations and their associations with systemic cancer therapy among older adults in nursing homes with advanced non-small cell lung cancer. J Geriatr Oncol. 2021 Feb 17:S1879-4068(21)00016-3. doi: 10.1016/j.jgo.2021.02.007. Epub ahead of print. PMID: 33610505.

Peracca SB, Fonseca A, Hines A, King HA, Grenga AM, Jackson GL, Whited JD, Chapman JG, Lamkin R, Mohr DC, Gifford A, Weinstock MA, Oh DH. Implementation of Mobile Teledermatology: Challenges and Opportunities. Telemed J E Health. 2021 Mar 1. doi: 10.1089/tmj.2020.0500. Epub ahead of print. PMID: 33691074.

Pimentel CB, Snow AL, Carnes SL, Shah NR, Loup JR, Vallejo-Luces TM, Madrigal C, Hartmann CW. Huddles and their effectiveness at the frontlines of clinical care: a scoping review. J Gen Intern Med. 2021 Feb 8. doi: 10.1007/s11606-021-06632-9. Epub ahead of print. PMID: 33559062.

Quach LT, Cho K, Driver JA, Ward R, Spiro A, Dugan E, Gaziano MJ, Djousse L, Rudolph JL, Gagnon DR. Social Characteristics, Health, and Mortality Among Male Centenarians Using Veterans Affairs (VA) Health Care. Res Aging. 2021 Mar 29:1640275211000724. doi: 10.1177/01640275211000724. Epub ahead of print. PMID: 33779393.

Rounds S, Harrington EO, McNamara SF. Building Research Capacity in Vascular Biology in Rhode Island. R I Med J (2013). 2021 Mar 1;104(2):50-53. PMID: 33648320.

Rumery K, Seo A, Jiang L, Choudhary G, Shah NR, Rudolph JL, Wu WC, Erqou S. Outcomes of coronavirus disease-2019 among veterans with pre-existing diagnosis of heart failure. ESC Heart Fail. 2021 Mar 16. doi: 10.1002/ehf2.13291. Epub ahead of print. PMID: 33728800.

Simeral JD, Hosman T, Saab J, Flesher SN, Vilela M, Franco B, Kelemen J, Brandman DM, Ciancibello JG, Rezaii PG, Eskandar EN, Rosler DM, Shenoy KV, Henderson JM, Nurmikko AV, Hochberg LR. Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia. IEEE Trans Biomed Eng. 2021 Mar 30;PP. doi: 10.1109/TBME.2021.3069119. Online ahead of print. PMID: 33784612.

Simons KV, Bower ES, Gillespie SM, Mills WL. Care Transitions to the Community from Veterans Affairs Nursing Homes: Experiences of Social Connection and Disconnection. J Am Med Dir Assoc. 2021 Mar;22(3):682-688. doi: 10.1016/j.jamda.2020.07.029. Epub 2020 Sep 15. PMID: 32943341; PMCID: PMC7490594.

Sorial MN, Huynh JP, Azzoli CG, Liauw JC, Brunault RD, Collins CM, Zullo AR. Survival outcomes associated with corticosteroid use before chemoimmunotherapy in patients with advanced lung cancer. Eur J Cancer. 2021 Mar;145:234-244. doi: 10.1016/j.ejca.2020.12.011. Epub 2021 Jan 8. PMID: 33431285; PMCID: PMC7935747.

Thomas KS, Corneau E, H Van Houtven C, Cornell P, Aron D, M Dosa D, M Allen S. Inequities in access to VA'S aid and attendance enhanced pension benefit to help Veterans pay for long-term care. Health Serv Res. 2021 Feb 25. doi: 10.1111/1475-6773.13636. Epub ahead of print. PMID: 33634467.

Tobin-Tyler E, Barton Laws M, Franco J, Jutkowitz E, Morton S. State Paid Family and Medical Leave Laws: Growth and Gaps in Coverage. Public Health Rep. 2021 Feb 26:33354920985807. doi: 10.1177/0033354920985807. Epub ahead of print. PMID: 33635739.

Ward HB, Mosquera MJ, Suzuki J, Mariano TY. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder. Neuromodulation. 2020 Apr;23(3):301-311. doi: 10.1111/ner.13108. Epub 2020 Feb 14.PMID: 32059080

Youn B, Wilson IB, Mor V, Trikalinos NA, Dahabreh IJ. Population-level changes in outcomes and Medicare cost following the introduction of new cancer therapies. Health Serv Res. 2021 Mar 7. doi: 10.1111/1475-6773.13624. Epub ahead of print. PMID: 33682120.

Young MJ, Lin DJ, Hochberg LR. Brain-Computer Interfaces in Neurorecovery and Neurorehabilitation. Semin Neurol. 2021 Mar 19. doi: 10.1055/s-0041-1725137. Epub ahead of print. PMID: 33742433.

Yuyun MF, Erqou SA, Peralta AO, Hoffmeister PS, Yarmohammadi H, Echouffo Tcheugui JB, Martin DT, Joseph J, Singh JP. Ongoing Risk of Ventricular Arrhythmias and All-cause Mortality at Implantable Cardioverter Defibrillator Generator Change: A Systematic Review and Meta-analysis. Circ Arrhythm Electrophysiol. 2021 Feb 6. doi: 10.1161/CIRCEP.120.009139. Epub ahead of print. PMID: 33554611.