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Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children with and Exposed to HIV
Major revisions within the last 6 months are as follows:
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Published a new section describing the approach to the prevention and management of COVID-19 in children with and exposed to HIV.
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Added recommendations for the use of pre-exposure prophylaxis, including COVID-19 vaccination in all children and the monoclonal antibody pemivibart in certain populations.
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Added recommendations for the treatment of COVID-19 with ritonavir-boosted nirmatrelvir, remdesivir, and/or corticosteroids, depending on the age of the child, clinical presentation, and risk factors for progression.
All updates are developed by the subject matter groups listed in Appendix B of the guidelines and reviewed by editors and relevant outside reviewers before finalization.
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