JILA’s Frequency Comb Breathalyzer Detects COVID-19 with Excellent Accuracy

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JILA’s Frequency Comb Breathalyzer Detects COVID-19 with Excellent Accuracy

Photo of woman breathing into medical collection bag with image of COVID-19 virus in background

JILA researchers have upgraded a breathalyzer based on Nobel Prize-winning frequency-comb technology and combined it with machine learning to detect SARS-CoV-2 infection in 170 volunteer subjects with excellent accuracy. Their achievement represents the first real-world test of the technology’s capability to diagnose disease in exhaled human breath.

Frequency comb technology has the potential to non-invasively diagnose more health conditions than other breath analysis techniques while also being faster and potentially more accurate than some other medical tests. Frequency combs act as rulers for precisely measuring different colors of light, including the infrared light absorbed by biomolecules in a person’s breath.

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