Targeting a Gene Fusion | Fat Cells to Starve Tumors | TIL Shrinks Solid Cancers, 04/09/2025

National Cancer Institute

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Cancer Information Highlights
From the National Cancer Institute
Updating you about cancer causes, prevention, screening, treatment, coping, and more
 
New from NCI
Targeted Therapy Approved to Treat Lung and Pancreatic Cancers with Rare Genetic Change
Zeno schematic   The Food and Drug Administration has approved zenocutuzumab (Bizengri) to treat people with pancreatic or non-small cell lung cancer whose tumors have a rare genetic change called an NRG1 fusion. The approval is based on a clinical trial in which the drug shrank tumors in a third of patients.

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Experimental Treatment Uses Engineered Fat Cells to “Starve” Tumors
Engineered fat cells   Researchers have developed a cancer treatment that uses fat cells engineered to consume nutrients like glucose. When implanted in mice, the engineered cells appeared to outcompete tumors for nutrients, shrinking tumors.

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Combination Immunotherapy Shrank a Variety of Metastatic Solid Cancers

A new form of tumor-infiltrating lymphocyte (TIL) therapy combined with pembrolizumab (Keytruda) caused tumors to shrink in nearly a quarter of patients with metastatic gastrointestinal cancers. This form of TIL therapy involves selecting immune cells (TILs) from a person’s tumor that actively recognize and attack specific proteins on their tumor cells, multiplying the TILs in a lab, and infusing them back into the patient.

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Childhood Nasopharyngeal Cancer

Nasopharyngeal cancer is cancer that forms in the upper part of the throat, behind the nose. In children, it is linked to Epstein-Barr virus. Visit our updated page to learn more about this cancer in children and how it is treated.

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