GI Problems | Whole-Body Effects of Cancer | Potential Drug Targets

National Cancer Institute

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Cancer Information Highlights
From the National Cancer Institute
Updating you about cancer causes, prevention, screening, treatment, coping, and more
 
Constipation and Cancer Treatment
Couple meets with doctor   If you’ve been treated for cancer, you may be familiar with a common side effect: constipation. This new page explains symptoms of constipation, what causes it, ways to prevent it, and how to treat it.

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Diarrhea and Cancer Treatment
Diarrhea  

Diarrhea is another unfortunate side effect of certain cancers and cancer treatments. Learn about the causes of diarrhea, symptoms it may cause, ways to manage it, and how to talk with your doctor.

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Bowel Obstruction and Cancer Treatment
Bowel obstruction  

A bowel obstruction is a serious problem that can be caused by cancer or cancer treatment. Learn more about bowel obstruction, such as what causes it, symptoms to look for, and how it is treated on this new page.

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Approaching Cancer as a Disease That Affects the Entire Body
FY26 Annual Plan  

The whole-body effects of cancer can decrease a person’s quality of life and allow tumors to spread to different parts of the body. The NCI Fiscal Year 2026 Annual Plan and Professional Judgment Budget Proposal explains how more investments are needed to unite various research areas for a clearer picture of how cancer communicates with and affects healthy organs and tissues.

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Trial Supports Uninterrupted Use of Imatinib for GIST

Study results showed that people with gastrointestinal stromal tumors (GISTs) who stopped imatinib (Gleevec) had a more rapid worsening of disease, a shorter time until resistance, and did not live as long as people who continued the therapy uninterrupted.

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Study Finds Hundreds of Potential Targets for Cancer Drugs
Drug targets image  

Using detailed information on genes and proteins from more than 1,000 tumors representing 10 cancer types, researchers have found hundreds of promising targets for existing drugs or possible new cancer drugs.

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New FDA Approval for Mesothelioma

The Food and Drug Administration (FDA) approval for pembrolizumab (Keytruda) now includes malignant pleural mesothelioma. Pembrolizumab is used with chemotherapy when the cancer has spread or cannot be removed by surgery.

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Contact Us
Cancer Information Specialist talks on a headset   Information specialists at NCI’s Cancer Information Service (CIS), NCI's contact center, are available to help answer your cancer-related questions in English and Spanish. This page tells you how to reach us by phone, chat, or email.