Clinical Trials Update from NCI, May 2024

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Clinical Trials
Updates from the National Cancer Institute
Clinical Trials News
Kidney cancer stages  

Pembrolizumab Provides First-Ever Overall Survival Improvement in Kidney Cancer


In a large clinical trial, treatment with pembrolizumab (Keytruda) after surgery helped people with kidney cancer live longer than those who got a placebo and standard monitoring. The findings mark the first time an adjuvant treatment for kidney cancer has improved survival.

Woman looking at computer

New Approach May Help People with Cancer Better Manage Depression, Pain, and Fatigue


People with cancer who have depression, pain, and fatigue are often referred to providers for treatment and must follow up to make an appointment. A recent clinical trial showed that integrating the assessment and treatment of symptoms as part of routine care may help them better manage these problems.

Lung cancer stage  

Alectinib Approved as Adjuvant Treatment for Lung Cancer


The Food and Drug Administration (FDA) has approved alectinib (Alecensa) given after surgery for people with lung cancer who have ALK-positive tumors. In a clinical trial comparing alectinib with chemotherapy, alectinib helped people live longer without their cancer returning.

Doctor and patient

FDA Approves Trastuzumab Deruxtecan for Any HER2-Positive Solid Cancer


Trastuzumab deruxtecan (Enhertu) can now be used to treat any advanced solid cancer that produces high levels of the protein HER2 (HER2-positive tumors). FDA’s accelerated approval was based on findings from three clinical trials.

Clinical Trials Information for Patients and Caregivers

Why Participate in a Clinical Trial?


Learn about the possible risks and benefits of joining a clinical trial and questions to ask about trials.


Steps to Find a Clinical Trial


Learn how to find the right clinical trial for you with the National Cancer Institute's six-step guide.

Clinical trials search  

Find NCI-Supported Clinical Trials


Use our search form to find a clinical trial or other research study that may be right for you or a loved one.

NCI-Supported Clinical Trials That Are Recruiting Patients 

Testing a New Imaging Agent to Detect Multiple Myeloma Recurrence


This phase 2 trial will test the ability of a radiotracer called 18F-fluciclovine to detect a relapse of multiple myeloma in people whose cancer is in remission. A radiotracer is a substance injected into the blood during imaging scans. Doctors want to see how the new radiotracer compares with the one currently used.


Modified T Cells and a Vaccine to Treat Metastatic Cancer


This clinical trial will test a combination of gene-modified tumor-infiltrating lymphocytes (TIL) and a vaccine designed to target cancer-specific proteins in people with cancer that has spread. Both the TIL therapy and vaccine target the same proteins. Doctors want to see if combining TIL therapy and a targeted vaccine is safe and how well it works to shrink tumors.


Testing a Diabetes Drug to Prevent Endometrial Cancer


This phase 2 clinical trial will test whether adding metformin, a drug commonly used to treat diabetes, to standard non-surgical treatment with megestrol acetate will help prevent endometrial intraepithelial neoplasia from turning into endometrial cancer.