A new treatment may help some people with advanced colorectal cancer live longer, according to results from an international clinical trial. The new regimen includes bevacizumab (Avastin) and the combination of trifluridine and tipiracil (Lonsurf).
In a clinical trial of people with multiple myeloma, giving motixafortide with filgrastim greatly increased the number of stem cells that could be collected. The treatment may allow more people with this cancer to get ideal numbers of stem cells for a transplant.
People with desmoplastic melanoma are likely to benefit from treatment with a single immunotherapy drug, pembrolizumab (Keytruda), according to results from a small clinical trial. Desmoplastic melanoma is a rare form of skin cancer.
In a clinical trial, the drug nirogacestat shrank tumors in 40% of people with desmoid tumors. Treatment with nirogacestat also greatly improved progression-free survival, pain, and physical functioning, compared with patients treated with a placebo.
Special Section: Transforming Clinical Trials
Transforming Cancer Clinical Trials for Better, Faster Results
NCI has helped launch the Pragmatica-Lung Study. This phase 3 randomized clinical trial is testing a two-drug combination to treat people with non-small cell lung cancer that has spread beyond the lungs (stage 4 cancer). Pragmatica-Lung represents a streamlined model for future cancer clinical trials that aims to increase accessibility to clinical trials.
See the study web page to learn more about the goals of this study, who is eligible to enroll, and why it is important.
Clinical Trials Information for Patients and Caregivers
Clinical trials are research studies that involve people. They are an essential step in developing new treatments, as well as screening and diagnostic tests, and finding ways to prevent cancer. This page can help people who want to learn more about what clinical trials are and why they are important.
Clinical trials may be closer to you than you think. Cancer clinical trials take place in cities and towns across the United States. Ask your health care provider about clinical trials near you or use NCI’s clinical trials search form to search within a set distance from your ZIP code.
This phase 2 trial will test the effect of adding pembrolizumab (Keytruda) to aldesleukin for people with melanoma or kidney cancer that has spread. Doctors want to see if the combination shrinks tumors for people in whom other treatments haven’t worked.
This phase 1/2 clinical trial will test pacritinib (Vonjo) for people experiencing chronic graft-versus-host-disease (GVHD) after a stem cell transplant that has not responded to at least two other treatments. Doctors will assess the safety of the treatment and see how well it works.
This phase 1/2 clinical trial will test a drug called zotiraciclib for people with high-grade gliomas with certain gene mutations that have not benefited from earlier treatments. Doctors want to determine the best dose and see how many people receiving the drug have remained stable 12 months after treatment.
