Results from three clinical trials suggest that CAR T-cell therapy may be better than standard treatments for people with B-cell NHL that has not responded to treatment or has relapsed after treatment.
Secondary surgery followed by chemotherapy can improve survival compared with chemotherapy alone for some people with ovarian cancer that has returned after earlier treatment, results from a large clinical trial show.
A program called ACCURE is showing promise in a clinical trial at reducing health disparities among Black and White people with breast and lung cancers. ACCURE involves system-wide changes at cancer centers to overcome structural and cultural barriers in patient care.
A clinical trial shows that a combination of the immunotherapy drugs ipilimumab (Yervoy) and nivolumab (Opdivo) is better than a combination of the targeted therapies dabrafenib (Tafinlar) and trametinib (Mekinist) as the first treatment for some people with metastatic melanoma. The DREAMseq trial included 265 people with metastatic melanoma whose tumors had BRAF V600 mutations.
For older adults with advanced cancer, a geriatric assessment can help direct their treatment, results from a new clinical trial show. In the study, patients whose care was guided by a geriatric assessment had fewer serious side effects and falls in their homes.
The NCI-COG Pediatric MATCH Clinical Trial page has been updated to reflect a recent change in recruitment status. NCI-COG Pediatric MATCH is an international cancer treatment clinical trial for children, teens, and young adults, aged 1 to 21, that is testing the use of precision medicine for childhood cancers.
Clinical Trials Information for Patients and Caregivers
Clinical trials are research studies that involve people. They are the final step in the process of developing new treatments, screening and diagnostic tests, and prevention methods for diseases, such as cancer. This page can help people learn more about clinical trials and why they are important.
Clinical trials can be confusing. This page offers questions that people who are thinking about taking part in a cancer treatment clinical trial can ask their health care providers.
This phase 1 trial will test the safety and tolerability of injecting LMB-100, an immunotoxin, directly into the tumor in combination with the immunotherapy ipilimumab (Yervoy) for people with malignant mesothelioma that cannot be removed by surgery. Researchers will also determine the best dose for a phase 2 clinical trial of the therapy.
This phase 1 trial studies the side effects and best dose of defined green tea catechin extract (Polyphenon E) in people with liver cirrhosis. Doctors want to see if the treatment will help prevent liver cancer and if it affects a molecule that may be related to the development of liver cancer.
This phase 1 trial will test CAR T-cell therapy that targets a protein called GPC3 found on the surface of advanced liver cancer cells. People with liver cancer that test positive for GPC3 and have not improved with chemotherapy will undergo the immunotherapy procedure. Doctors want to see if CAR T-cell therapy using T cells genetically modified to recognize GPC3 is safe.
