Clinical Trials Update from NCI, June 2021

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Clinical Trials
Updates from the National Cancer Institute
Clinical Trials News
KRAS lung cancer  

FDA Approval of KRAS Inhibitor Sotorasib for Lung Cancer Hailed as Milestone

The Food and Drug Administration (FDA) has granted accelerated approval to sotorasib (Lumakras), the first KRAS-blocking drug to clear the regulatory hurdle. The approval, which covers the use of sotorasib to treat some patients with advanced lung cancer, is based on initial results from a phase 1/2 clinical trial dubbed CodeBreaK 100.

Hairy cell leukemia  

Drug Combination Leads to Long-Lasting Remissions for Hairy Cell Leukemia

In a small clinical trial, vemurafenib (Zelboraf) and rituximab (Rituxan) helped 85% of participants stay in remission for nearly 3 years. The study involved 30 people with hairy cell leukemia that had come back or had not responded to previous treatment.

Esophagus x-ray  

Nivolumab-Based Combinations Improve Survival in Advanced Esophageal Cancer

A treatment regimen that combines the immunotherapy drug nivolumab (Opdivo) with either another immunotherapy drug or chemotherapy may be a new initial treatment option for people with advanced esophageal cancer, according to results of a large clinical trial.


Nivolumab and Relatlimab Combination Shows Promise in Advanced Melanoma

People with advanced melanoma treated with two immunotherapy drugs—nivolumab (Opdivo) and a new drug called relatlimab—lived longer without their cancer getting worse than those treated only with nivolumab, results from a large clinical trial show.

Clinical Trials Information for Patients and Caregivers

Steps to Find a Clinical Trial

This step-by-step guide is intended to help people who wish to look for a clinical trial on their own. The guide includes questions to ask about clinical trials and points to several sources for clinical trial information.


NIH Clinical Trials and You: The Basics

The National Institutes of Health (NIH) Clinical Trials and You website is a resource for people who want to learn more about clinical trials. This page provides answers to common questions about taking part in a clinical trial.

Search for a clinical trial  

Find NCI-Supported Clinical Trials


Use our search form to find a clinical trial or other research study that may be right for you or a loved one.


NCI-Supported Clinical Trials That Are Recruiting Patients 

Combining Experimental Therapies for Advanced Pancreatic Cancer

This phase 1/2 trial will test the addition of stereotactic body radiation therapy (SBRT) to a combination of two experimental immunotherapy drugs for people with inoperable pancreatic cancer. Doctors want to see if adding SBRT to immunotherapy will shrink tumors enough for people to receive surgery.


Combining Drug Treatments for Hairy Cell Leukemia

This phase 1 trial will test the safety of adding the immunotoxin moxetumomab pasudotox (Lumoxiti) to rituximab (Rituxan) for people with relapsed hairy cell leukemia (HCL). Moxetumomab pasudotox is FDA approved for relapsed HCL. And rituximab is commonly used to treat the disease. Researchers want to see if combining the drugs can fight HCL better.


Comparing Two Methods to Follow Patients with Pancreatic Cysts

This trial will evaluate two different screening strategies for non-cancerous pancreatic cysts to determine which works best at detecting early signs of cancer. Doctors want to compare more frequent versus less frequent monitoring to learn which method leads to better results for people with pancreatic cysts.