The Food and Drug Administration has granted regular approval for sacituzumab govitecan (Trodelvy) to treat people with locally advanced or metastatic triple-negative breast cancer. The approval is based on results from a confirmatory phase 3 clinical trial.
In a recent phase 2 clinical trial, using brentuximab vedotin (Adcetris) instead of the chemotherapy drug vincristine allowed some children and teens with advanced Hodgkin lymphoma to avoid radiation therapy—and the long-term health problems that can come with it.
Results from an NCI-supported phase 1 clinical trial show that combining topotecan (Hycamtin) with the experimental drug berzosertib shrank tumors in some patients with small cell lung cancer. Additional trials of the combination are planned.
Clinical Trials Information for Patients and Caregivers
Everyone who takes part in a clinical trial has their own reasons for doing so. Read some stories of people who participated in clinical trials on this page shared by NCI's Division of Cancer Prevention.
Taking part in a cancer treatment clinical trial is a big decision. This page presents a list of questions to ask your doctor about before deciding to participate.
This trial will compare how well two surgical procedures work in reducing the risk of ovarian cancer in women with mutations in the BRCA1 gene. One group of women will have their ovaries and fallopian tubes removed. The other women will have only their fallopian tubes removed. Women with mutated BRCA1 genes face a much higher risk of ovarian and other cancers.
This phase 3 trial studies how well bupropion (Wellbutrin) works in reducing cancer-related fatigue in survivors of stage I, II, or III breast cancer. Bupropion is usually used to treat depression, as well as to help people quit smoking.
This phase 2 study will use positron emission tomography/computed tomography (PET/CT) with radioactive material to try to identify places in the body where prostate cancer has spread. The trial is investigating whether using this type of imaging scan before the prostate is surgically removed can predict if prostate cancer will return.
