Cancer Information Highlights, January 22, 2020

National Cancer Institute

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Cancer Information Highlights
From the National Cancer Institute
Updating you about cancer causes, prevention, screening, treatment, coping, and more
 
New from NCI
New Treatments Emerge for Metastatic HER2-Positive Breast Cancer
Breast cancer cells with strong HER2 amplification (shown in red) that have spread to the lymph nodes.   Two drugs that block the same target in different ways show promise in two separate clinical trials for women who have received previous treatment for HER2-positive breast cancer that has spread. Learn more about these drugs and how they may factor into treatment for women with HER2-positive breast cancer.
Targeted Therapy Approved for Recurrent Bladder Cancer
The antibody component of enfortumab vedotin binds to the nectin-4 protein on bladder cancer cells. Once enfortumab enters the cell, the MMAE is released and causes the cell to die.   The Food and Drug Administration (FDA) granted accelerated approval to enfortumab vedotin-ejfv (Padcev) for people with advanced bladder cancer that has progressed despite treatment with two previous therapies. Learn more about this drug, the study that led to this approval, and plans for the future.
New Chemotherapy Drug Extends Survival for People with AML

Learn more about a large clinical trial that showed that maintenance therapy with the experimental drug CC-486 increased survival for adults with acute myeloid leukemia (AML).
New Clues about Why Melanoma Spreads

Read about a new NCI-supported study in mice that provides insights into why some melanomas are more likely to spread than others—and points to a potential treatment target.

Drug Information Updates
New Drug for Breast Cancer

We’ve added a new drug information summary for fam-trastuzumab deruxtecan-nxki (Enhertu). FDA recently approved the drug to treat HER2-positive breast cancer that cannot be removed by surgery or has spread to other parts of the body in women who already received at least two other therapies.
 
Also of Interest
Infographic—NCI at a Glance

Discover more about what the National Cancer Institute does, what we fund, and some highlights from our long history in leading cancer research.
Targeted Therapy to Treat Cancer

Targeted therapy is a type of cancer treatment that targets the changes in cancer cells that help them grow, divide, and spread. Learn how targeted therapy works against cancer and about side effects that may occur.