Based on data from two clinical trials, the Food and Drug Administration (FDA) has granted a label change for the drug nilotinib (Tasigna), allowing patients with chronic myelogenous leukemia who have been using nilotinib for at least 3 years and been in remission for an extended period to stop treatment.
Results from two clinical trials form the basis for the FDA’s approval of a new targeted therapy for adult patients with advanced neuroendocrine tumors that affect the pancreas or gastrointestinal tract, known as GEP-NETs. Lutetium Lu 177 dotatate is the first radioactive drug approved to treat these rare cancers.
FDA has expanded the approval of abiraterone (Zytiga) for men with prostate cancer based on the results from a large phase 3 trial. The agency approved abiraterone for men with metastatic prostate cancer that is responsive to hormone-blocking treatments (castration-sensitive) and is at high risk of progressing.
This page introduces the issue of patient safety in clinical trials. It includes a video further explaining how trial investigators guarantee patient safety.
Informed consent is a process through which you learn details about the trial before deciding whether to take part. This page explains the informed consent process.
This phase 1 study is designed to test a shortened course of highly focused radiation therapy in men with prostate cancer that has returned following surgery to remove all or part of the prostate (prostatectomy). Doctors want to see if the modified radiation therapy regimen can be delivered without increased side effects.
This phase 2 study is testing the drug palmolidomide in patients between the ages of 1 and 21 who have recurring or progressive primary brain tumors, including high-grade glioma, medulloblastoma, ependymoma, and DIPG. Doctors will assess the efficacy, safety, and tolerability of pomalidomide in these patients following at least one prior therapy.
This phase 1b study will examine the safety, dosing, and efficacy of anetumab ravtansine as a single agent or in combination with other drugs for patients with mesothelin-expressing advanced solid tumors. Mesothelin is a protein that is often overabundant on cells of some cancer types, including mesothelioma, pancreatic cancer, ovarian cancer, and cholangiocarcinoma.