Goldenseal: Science and Safety

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U.S. Department of Health & Human Services  /  National Institutes of Health

Background 

  • Goldenseal is a plant native to North America. It is grown commercially in the United States, especially in the Blue Ridge Mountains. 
  • Goldenseal is promoted as a dietary supplement for a variety of conditions, including colds, hay fever, and digestive upsets. 

How Much Do We Know? 

  • Very little research has been done on the health effects of goldenseal. 

What Have We Learned? 

  • The scientific evidence does not support the use of goldenseal for any health-related purpose. 
  • Berberine, a substance found in goldenseal, has been studied for a variety of health-related uses. However, when people take goldenseal orally, very little berberine may be absorbed by the body or enter the bloodstream. Therefore, study results on berberine may not apply to goldenseal. 

What Do We Know About Safety? 

  • Goldenseal might be safe for short-term use for most adults. There isn’t enough reliable information to know whether it’s safe for long-term use. 
  • Goldenseal may change the way your body processes many medications. If you’re taking medicine, talk with your health care provider before using goldenseal. 

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