Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) are two chemically related substances that have been studied for osteoarthritis. DMSO is applied to the skin. MSM is sold as a dietary supplement, either alone or in combination with other ingredients.
Only a small amount of research has been done on DMSO or MSM for osteoarthritis. No conclusions can be reached about whether either of these substances is helpful.
Side effects of DMSO include digestive upset, skin irritation, and a garlic-like taste, breath, and body odor. Side effects of MSM include allergic reactions, digestive upsets, and skin rashes.
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