Second Quarter Cost of Living 2021 Missouri had the 8th lowest cost of living in the United States for the second quarter 2021. In general, the most expensive areas to live were Hawaii, Alaska, the Northeast, and the West Coast. The least expensive areas were the Midwest and Southern states. For the past 18 quarters, Missouri has been in the top 10 for lowest cost of living in the nation. Cities across the nation participate in the Council for Community & Economic Research (C2ER) survey on a volunteer basis. Price information in the survey is governed by C2ER collection guidelines.
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