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The Vaccine Integrity Project (VIP) is expected to release their review of the safety and effectiveness of COVID-19, influenza, and respiratory syncytial virus (RSV) vaccines in Evidence Reviews. This information can be used by professional medical organizations to make decisions regarding immunization recommendations for the 2026-27 respiratory season. MDH respiratory vaccination guides and updated vaccination protocol templates will be available on Immunization Best Practices. To sign up for updates visit Influenza Vaccine Information for Health Professionals and enter your email.
New mRNA influenza vaccine
The FDA has approved MFLUSIVA, the first mRNA-based influenza vaccine in the U.S. It is approved for adults 50 years of age and older. This vaccine is found to be 27% more effective than standard-dose influenza vaccine for adults in this age group. It provides another option for protecting older adults against influenza and its complications. Patients are more likely to experience mild, short-term side effects from the mRNA influenza vaccine than other vaccine products. However, these symptoms generally only lasted one to two days and no serious safety concerns were identified.
RSV season begins
Sept. 1 marks the start of maternal RSV vaccination for eligible pregnant patients. A single dose administered between 32-36 weeks' gestation can help protect infants from severe RSV illness during their first months of an infant’s life. Infants who are not protected through maternal vaccination can receive RSV monoclonal antibody (mAb) products beginning Oct. 1. Recent studies have shown that both maternal vaccination and infant RSV mAbs are very effective against RSV in hospitalized infants. For more information visit Respiratory Syncytial Virus (RSV) Information for Health Professionals.
MnVFC influenza and RSV mAb shipping now
MnVFC influenza vaccine for the 2026-27 season started shipping earlier this month and RSV mAbs will begin shipping at the end of this month. We will continue to ship orders as doses become available from the manufacturers. MnVFC-enrolled providers can submit additional requests for doses at any time in MIIC.
In January the Centers for Disease Control and Prevention (CDC) released a new immunization schedule, drastically reducing the number of routinely recommended vaccines for children and adolescents, including the human papillomavirus (HPV) vaccine. While a federal court order issued in March put these changes on hold, these recent actions have prompted renewed discussion about the HPV vaccine.
In May, the Vaccine Integrity Project: Evidence Review released HPV Vaccine Resources. It’s a comprehensive and systematic literature review evaluating the safety and effectiveness of the HPV vaccine that strongly supports two doses of HPV vaccine for adolescents initiating the series at 9-14 years of age, and three doses for those initiating the series at 15 years or older.
Reducing the series to a single dose of the HPV vaccine is not recommended for adolescents in the U.S. While emerging evidence suggests that a single dose may provide similar clinical protection in females, current research is insufficient in determining whether one dose provides long-term cancer protection or is effective in males.
MDH continues to endorse immunization schedules from the AAP and American Academy of Family Practice (AAFP). These schedules are consistent with the VIP’s evidence review supporting a two or three dose series depending on the age at initial vaccination. For more information, visit Vaccine Recommendations and Access for Minnesotans.
Immunize Minnesota is the new statewide immunization coalition focused on ensuring access, improving immunization rates, and increasing vaccine confidence through education and partnership. The coalition grew from Minnesota Public Health Association (MPHA)’s “Vaccinations in Minnesota” Workgroup. MDH serves as a non-voting technical advisor on Immunize Minnesota’s steering committee, led by co-chairs, Munira Malimisaq, NP and CEO of Inspire Change Clinic, and Caleb Schultz, MD, community and public health advocate.
Immunize Minnesota held its first official meeting on Aug. 10. Everyone is invited to attend the meetings held on the second Mondays of every month. Visit Immunize Minnesota to learn more about the people and organizations dedicated to protecting all Minnesotans from vaccine-preventable diseases, and how you can participate.
The vaccine-preventable disease (VPD) surveillance team recently published a paper in the journal Public Health Reports that analyzed the Impact of the 2024 Council of State and Territorial Epidemiologists’ (CSTE) Varicella Case Definition and Classification on Varicella Cases Reported in Minnesota. Case definitions and classifications are definitions published by CSTE to establish a national, standardized definition of what is considered a true case of chickenpox.
The updated definition improves the VPD surveillance program’s ability to capture and define chickenpox cases in the era of varicella immunization, in which a large proportion of all cases are milder breakthrough cases occurring in vaccinated people. The new definition highlights the importance of laboratory confirmation, given that breakthrough cases can be easily mistaken for other rash illnesses.
With measles cases continuing to rise nationally, MDH's VPD section and the Midwest Analytics and Disease Modeling Center (MADMC) released the “Midwest EpiView: MMR Coverage and Measles” tool in April. It is a timely resource for tracking measles, mumps, and rubella (MMR) vaccination coverage and measles case trends statewide.
Building on that tool, “Midwest EpiView: Chickenpox (Varicella)” was launched in early August. This interactive dashboard lets users explore varicella vaccination coverage statewide in schools (by grade level) and childcares, and chickenpox case data by county and age (2013–2025). With varicella vaccination coverage on the decline, the tool helps health departments, school nurses, and immunization coordinators pinpoint where to focus their outreach.
Access both tools and other resources on School of Public Health University of Minnesota Midwest Analytics and Disease Modeling Center (MADMC): Analytic Tools & Resources.
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