 Hello Immunization Partners,
Please share this information with staff and colleagues.
On September 12, 2024, the Centers for Disease Control and Prevention (CDC) published an MMWR, Use of Haemophilus influenzae Type b–Containing Vaccines Among American Indian and Alaska Native Infants: Updated Recommendations of the Advisory Committee on Immunization Practices ― United States, 2024. What follows is a summary of those recommendations.
On June 26, 2024, the Advisory Committee on Immunization Practices (ACIP) recommended that hexavalent Vaxelis™ (diphtheria and tetanus toxoids and acellular pertussis, inactivated poliovirus, Hib conjugate, and hepatitis B vaccine [DTaP-IPV-Hib-HepB]) should be included with monovalent PRP-OMP (PedvaxHIB®) in the preferential recommendation for American Indian /Alaska Native (AI/AN) infants based on the Hib component.
Summary of Recommendations for Use of Hib-Containing Vaccines Among American Indian and Alaska Native Infants and Children:
Primary Series:
- DTaP-IPV-Hib-HepB (Vaxelis™) is included with monovalent PRP-OMP (PedvaxHIB®) in the preferential recommendation for American Indian and Alaska Native infants. The basis for this recommendation is the Hib component of PRP-OMP (PedvaxHIB®).
- A primary Hib vaccination series consisting of either 1) monovalent PRP-OMP (2-dose series at ages 2 and 4 months) or 2) DTaP-IPV-Hib-HepB (3-dose series at ages 2, 4, and 6 months) is preferred over other Hib vaccine formulations for AI/AN infants. If the first Hib vaccine dose is delayed by more than one month, the recommended catch-up schedule should be followed.
Booster Doses:
- DTaP-IPV-Hib-HepB (Vaxelis™) is only indicated for use in infants aged 2, 4, and 6 months and should not be used for the booster doses of Hib, DTaP, or IPV vaccines (Table 1).
- For the booster dose of Hib vaccine, no vaccine formulation is preferred for AI/AN children; any Hib vaccine except DTaP-IPV-Hib-HepB (Vaxelis™) should be used.
- In clinics caring for AI/AN children, stocking monovalent PRP-OMP (PedvaxHIB®) for the Hib booster dose would maintain parent, guardian, and provider flexibility to choose this vaccine for the primary Hib series. Stocking a PRP-T vaccine (ActHIB® or Hiberix®) for the Hib booster dose also is an option (Table 2).
- If DTaP-IPV-Hib-HepB (Vaxelis™) is inadvertently administered for the booster dose or doses of Hib, DTaP, or IPV vaccines, the dose of the corresponding component does not need to be repeated when the proper spacing of doses is maintained.
Thank you for all you do!
Oakland County Health Division, Immunization Action Plan
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