Cardiovascular Effects of Multipollutant Exposure: Mechanisms and Interactions
Fine particulate matter (PM2.5) and ozone are both common
air pollutants known to be associated with heart-related health impacts.
However, little is known about whether their effects are altered when they
occur together as a mixture. The goal of this study was to determine whether
there were significant interactions in the biological responses from concurrent
exposures to PM2.5 and ozone. This was explored in two ways. First, in the
laboratory setting, mice were exposed to concentrated ambient particles (CAPs)
or to CAPs administered together with 0.2 ppm ozone, which was generated
in the laboratory and metered in along with the CAPs. The second approach was
to contrast the health outcomes of CAPs exposures to particles formed or aged
during periods of relatively high photochemical activity (i.e.
spring/summer), which increases ambient ozone concentrations,
with outcomes of exposures to fall/winter particles which are associated
with lower ozone concentrations. Researchers also examined whether
differences in the chemical constituents of the particles might explain
possible health outcome differences.
DATE: June 1, 2018
TIME: 10:00 a.m.
LOCATION: California Environmental Protection Agency
Air Resources Board | Sierra
Hearing Room
1001 I Street
Sacramento, California 95814
Speaker Biography
Michael
T. Kleinman, Ph.D., is a Professor and Co-Director of the Air Pollution
Health Effects Laboratory in the Department of Medicine at the
University of California, Irvine. Prior to joining the faculty at UCI in
1982, he directed the Aerosol Exposure and Analytical Laboratory at
Rancho Los Amigos Hospital in Downey, California. Dr. Kleinman's current
research has focused on toxicological studies of airborne contaminants
using laboratory animals. Professor Kleinman has published more than 100
articles in peer-reviewed journals dealing with the uptake and
dosimetry of inhaled pollutants, cardiopulmonary and immunological
responses associated with inhalation of PM2.5, health effects of acidic
and non-acidic aerosols, and studies of the effects of mixtures of
particles with other pollutants such as ozone, formaldehyde, sulfur
dioxide, and nitrogen dioxide. Dr. Kleinman's previous studies examined
cardiopulmonary effects of concentrated ambient ultrafine, fine and
coarse particles using animal models of susceptible human populations.
His current studies address the role of organic and inorganic
constituents of particulate matter and ozone mixtures in the development
or exacerbation of heart disease. Dr. Kleinman has been studying the
health effects of exposures to particles and gases found in ambient air
for more than 30 years.
Dr.
Kleinman is a member of the U.S. EPA Board of Scientific Counselors and
is a member of the Science Advisory Panel for the Bay Area Air Quality
Management District. Professor Kleinman is Chairman of the State of
California's Scientific Review Panel on Toxic Air Contaminants.
Professor Kleinman holds a M.S. in Chemistry from the Polytechnic
Institute of Brooklyn and a Ph.D. in Environmental Health Sciences from
New York University.
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