Upcoming Deadlines for Funding in these Topics of Special Interest

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Office of Translational Alliances and Coordination

September 6 Deadline for SBIR/STTR Grants

The next NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) application deadline is Tuesday September 6, 2016, 5 pm local time. The National Heart, Lung, and Blood Institute (NHLBI) welcomes all investigator-initiated projects within our mission through the Omnibus funding opportunities:  

  • SBIR (PA-16-302) and STTR (PA-16-303) Omnibus Solicitations for Phase I, Phase II, and Fast-Track applications
  • SBIR Direct-to-Phase II Pilot (PAR-14-088) for Direct to Phase II applications.

Note: the standard SBIR/STTR due date of September 5 falls on a Federal holiday, so the deadline for SBIR/STTR is September 6.

Submit via ASSIST

ASSIST helps streamline the electronic submission process. Try submitting with ASSIST before the September 6 deadline! Questions? http://bit.ly/ASSIST_Info

Use SBIR/STTR Application Instructions, Forms Version D

Make sure you’re using the new “Forms Version D” SF424 SBIR/STTR Application Guide and Supplemental Grant Application  Instructions: http://bit.ly/SF424-SB-formsD

Find additional useful resources from NIH SBIR: http://bit.ly/SBIR_Resources

Contact the eRA Service Desk (http://bit.ly/eRA_ServiceDesk) for electronic submission questions.

Toll-free: 1-866-504-9552
Phone: 301-402-7469
Hours: Mon-Fri, 7 a.m. to 8 p.m. Eastern Time (closed on federal holidays)

Additional Funding Opportunities Due Fall 2016 

  • September 6 - New Technologies for Viral Hepatitis (SBIR PA-15-077 STTR  PA-15-076)
  • September 6 - Commercialization Readiness Pilot (CRP) Program: Technical Assistance for Phase II Awardees - (SB1 PAR-16-026, Notice about NHLBI participation NOT-HL-15-283)
  • October 14 – Bioreactors for Reparative Medicine (SBIR RFA-HL-15-008 STTR RFA-HL-15-004 D2P2 RFA-HL-15-017)
  • October 15 - Onsite Tools and Technologies for Heart, Lung, and Blood Clinical Research Point-of-Care (STTR RFA-HL-14-017)
  • November 9 – Human Cellular Models for Predicting Individual Responses to Cystic Fibrosis Transmembrane Conductance Regulator- Directed Therapeutics (SBIR RFA-HL-15-027)

View all NHLBI targeted funding opportunities on our website (http://bit.ly/NHLBI-SBIR-FOA).


October 21 Deadline - FY2017 NIH/CDC SBIR Contract Solicitation Now Available

Register for the August 24, 2 pm EDT pre-proposal webinar: HERE

Proposals due October 21, 5 pm EDT

The annual NIH and CDC SBIR Contract Solicitation (PHS2017-1) has been released (http://bit.ly/PHS2017-1). New electronic submission process for contract proposals through the Contract Proposal Submission (eCPS) website: https://ecps.nih.gov/sbirsttr. See NOT-OD-16-123 for all NIH and CDC topics, contracting officer contact information, and other details. 

NHLBI Topics for FY2017

  • 098 Testing and Validation of Technologies for Inclusion in the CART Demonstration Project for Collaborative Aging Research
  • 099 Inhalational 5A Apolipoprotein A-I Mimetic Peptide for the Treatment of Asthma (SBIR-TT)
  • 100 MRI Myocardial Needle Chemoablation Catheter
  • 101 Membranous Ventricular Septal Defect (pmVSD) Transcatheter Occluder System
  • 102  Transcatheter Occluder Device for Paravalvular Leaks

Please direct all inquiries on the contract process or topics to:

Mr. John Taylor, taylorjc@nhlbi.nih.gov

All questions must be submitted by September 1, 2016.


    NHLBI Small Business Topics of Special Interest (TOSI)

    Read NOT-HL-16-332

    The NHLBI accepts investigator-initiated grant applications relevant to the NHLBI mission through the Omnibus Grant Solicitations. NHLBI has identified specific Topics of Special Interest though we also encourage mission-aligned applications for innovative technologies outside these targeted areas. Applications for TOSI are submitted in response to the Omnibus Grant Solicitations (SBIR PA-16-302, STTR PA-16-303, and Direct to Phase II SBIR PAR-14-088). 

    TOSI are not the same as the list of topics approved for awards over statutory budget limitations; for these waiver topics, please see Appendix A of the Program Descriptions and Research Topics document.

    • HLS17-01 Animal and Cellular Models: for rare non-malignant and pre-malignant (MDS & MPD) hematologic disorders; for complications associated with thrombosis; for transfusion of blood products or cell-based  therapies
    • HLS17-02 Research tools:  Imaging, reagents, assays including microassays, microfluidics, bioinformatics and nanotechnology for investigations of blood diseases, transfusion and cellular therapies
    • HLS17-03 Diagnostics: devices, biomarkers, imaging, and assays for non-malignant blood disorders
    • HLS17-04 Therapeutics:  drugs, blood product and cellular therapies, and gene therapy for non-malignant blood disorders
    • HLS17-05 E-medicine Apps for patients and medical professionals to improve the management of and reduce the impact of non-malignant blood diseases
    • HLS17-06 Development of molecular imaging reagents/techniques and nanotechnology-based drug delivery systems that detect and allow for specific targeting of lung diseases
    • HLS17-07 Development of reagents and methods to identify and isolate stem/progenitor cells, and direct differentiation to specific functional organ units.
    • HLS17-08 Development and validation of techniques(or algorithms) to study the microbiome in situ
    • HLS17-09 Characterization and in vivo or in vitro applications of miRNA panels that target lung-resident mesenchymal or fibroblast cells and directly or indirectly promote lung repair or regeneration.
    • HLS17-10 Development of high throughput methods to apply microfluidics technology in discovery of molecular profiles (DNAs, RNAs, proteins, or metabolites) in a large number of sputum or exhaled breath condensate samples collected from lung disease patients. 
    • HLS17-11 High-definition, conformal, biocompatible mesh technologies made from nanoscale materials are revolutionizing electronic-tissue interfaces. 
    • HLS17-12 Develop new and improved methods to assess, monitor, or predict cardiovascular toxicity of therapeutic agents
    • HLS17-13 For citizens returning to an urban environment after release from prison or jail, develop and validate mobile app solutions they can use to improve their health outcomes related to cardiovascular diseases including but not limited to hypertension. 
    • HLS17-14 New animal models for the study of chronic venous insufficiency (CVI) and post-thrombotic syndrome, and innovative approaches for their prevention and treatment.
    • HLS17-15 Development of mechanical circulatory support devices for individuals with congenital heart disease and single ventricle physiology after Fontan surgical palliation.
    • HLS17-16 Novel non-invasive strategies that detect early subclinical changes in cardiac structure, function, and /or tissue are needed to improve detection and monitoring of chemotherapy-induced cardiac injury in order to improve cardioprotection and effectiveness of cancer therapeutics. 
    • HLS17-17 Develop innovative technology and/or service delivery models or designs to increase the adoption, uptake, and sustainability of evidence-based guideline recommendations for the management of heart, lung, blood, and sleep disorders. These should include multi-level (health systems, provider, and patient) facets and benefit ethnic/racial minority groups, rural populations, and low socioeconomic status groups. 


      Meet NHLBI Small Business Experts

      9/13 -  RESI 2016 – Boston, MA

      9/19 - 9/20 -  Arizona Bioscience Week (AZBio) – Phoenix, AZ

      9/29 - 9/30 - 14th Annual Dartmouth Device Development Symposium – Woodstock, VT

      10/17 - 10/19 -  AdvaMed 2016 – Minneapolis, MN

      10/18 - 10/19 -  BIO Investor Forum – San Francisco, CA

      11/1 - NHLBI Innovation Conference – New York City, NY

      11/1 - 11/3 -  SSTi 2016 Annual Conference – Columbus, OH

      11/2 - 11/3 - Life Sciences Summit – New York City, NY

      11/13 - 11/15 - Partnering for Cures – New York City, NY

      11/15 - 11/17 - 18th Annual HHS SBIR/STTR Conference - Orlando, FL