DCP Updates: A Translational Review of MCDs, Possible Biomarker for Lynch Patients, Cancer Pain Research, AACR, and More

National Cancer Institute sent this bulletin at 04/02/2024 12:27 PM EDT

Latest News

Cancer Screening with Multicancer Detection Tests: A Translational Science Review

An illustration of a magnifying glass hovered over a blood vessel

In this review in CA: A Cancer Journal for Clinicians, NCI authors describe how multicancer detection (MCD) tests, while easy to administer, require much more evidence from prospective clinical trials before being ready for widespread population-based screening. These trials, including from NCI’s Cancer Screening Research Network, aim to provide some of this much-needed data to evaluate MCD test efficacy, accuracy, and the potential harms of overdiagnosis and overtreatment.

Read the article.

Frameshift Mutations in Peripheral Blood as a Biomarker for Surveillance of Lynch Syndrome

In this article in the Journal of the National Cancer Institute, NCI’s Robert Shoemaker Ph.D., Song Yurong, Ph.D., and Holli Loomans-Kropp, Ph.D., M.P.H., et al., identified a peripheral blood biomarker for surveillance of people with Lynch Syndrome. Cancers in people with Lynch syndrome show high microsatellite instability and frame shift mutations at specific spots in the genome. After further development and validation, this biomarker looking for those genomic changes may help reduce the frequency of invasive screening needed for Lynch Syndrome mutation carriers and provide feedback on the effectiveness of new interventions.

Read the article.

Resources for Cancer Immunoprevention Research

This commentary by NCI DCP staff, NCI Resources for Cancer Immunoprevention Research, in Cancer Immunological Research, looks at DCP’s support of immunoprevention research, including basic, translational, and clinical research activities.

Read the commentary.

Cancer Pain Research Addressing Multiple Causes, Multiple Managements

Pain occurs in up to 50% of patients with cancer.

As improved cancer treatments have led to increased cancer survivorship, cancer survivors are now living longer with chronic pain. NCI is supporting research (search key word: pain) to address this issue.

Read the Cancer Prevention Science Blog.

Upcoming Events

American Association for Cancer Research Annual Meeting 2024

Friday, April 5 - Wednesday, April 10
San Diego, CA

Learn about NCI Division of Cancer Prevention presentations at the upcoming American Association for Cancer Research (AACR) Annual Meeting. Presentation topics include funding opportunities in cancer prevention, interception, and symptom science; research resources and workforce activities; multi-cancer detection tests and risk screening; future research needs; and more.

See AACR Sessions Featuring NCI Division of Cancer Prevention staff

See PREVENT-supported Project Presentations at AACR

DCP Early Career Scientist Spotlight Research Seminar Series

Friday, April 19
11:00 a.m.-Noon ET
Advanced registration is required

Jonathan Villena-Vargas, M.D., a thoracic surgeon, and early-stage investigator at Weill Cornell Medicine, will give a talk titled, “CD8+ T Cell Clonal Dynamics in Response to ICB Therapy in Surgically Resectable NSCLC.”

The DCP Early Career Scientist Spotlight Research Seminar Series highlights nominated early career scientists who are advancing research within the areas supported by DCP.

Immuno-Oncology Translational Network Capstone Meeting

Tuesday, May 14 -Wednesday, May 15
Advance registration required
Registration closes Tuesday, May 7.

Consider attending the hybrid Immuno-Oncology Translational Network (IOTN) Capstone Meeting to learn about scientific accomplishments in immuno-oncology across the Cancer Moonshot^sm network. Attendance options include in person at Masur Auditorium (Building 10, NIH Bethesda main campus) or virtual.

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Division of Cancer Prevention

National Cancer Institute National Institutes of Health U.S. Department of Health and Human Services