Clinical Trials Update from NCI, September 2023

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Clinical Trials
Updates from the National Cancer Institute
Clinical Trials News
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Cholesterol Drug May Help Protect the Heart during Chemotherapy for Lymphoma

The cholesterol-lowering drug atorvastatin (Lipitor) may help reduce the risk of heart failure in people with lymphoma who receive anthracyclines, results from a clinical trial suggest. Anthracyclines, such as doxorubicin, are a type of chemotherapy that is used to treat many types of cancer.

Illustration of stage 3 endometrial cancer  

FDA Approves Dostarlimab for Endometrial Cancer

The Food and Drug Administration (FDA) has approved dostarlimab (Jemperli) in combination with chemotherapy to treat people with endometrial cancer. It is approved for use with chemotherapy for primary endometrial cancer that has spread or has come back after earlier treatment. The approval was based on the results of a phase 3 clinical trial called Ruby.


NCI Minute: Immunotherapy for a Rare Cancer


This video talks about FDA approval of the immunotherapy drug atezolizumab for treatment of advanced alveolar soft part sarcoma. The approval was based on results from an NCI-supported clinical trial.

Clinical Trials Information for Patients and Caregivers

Cancer Currents Blog—Clinical Trials Results

NCI’s cancer research news blog, Cancer Currents, reports on findings from cancer clinical trials, with commentary from leading researchers on how the trial results will affect patient care.


CCR Clinical Trials for Patients

Physicians in NCI’s Center for Cancer Research (CCR) develop and conduct a wide range of clinical trials to develop new medicines and treatments for patients with cancer, HIV, or immunodeficiency disorders. Learn more about CCR clinical trials on the center’s clinical trials patient information page.

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Find NCI-Supported Clinical Trials

Use our search form to find a clinical trial or other research study that may be right for you or a loved one.

NCI-Supported Clinical Trials That Are Recruiting Patients 

Drug Combination for Advanced Kidney Cancer

This phase 1/2 clinical trial will test the drug combination of palbociclib (Ibrance) and sasanlimab for people with clear cell renal cell carcinoma or papillary renal cell carcinoma. This study will help establish the best dose of this treatment and doctors will see how many people’s tumors shrink.


CAR T-Cell Therapy for B-Cell Cancers

This phase 1 trial will determine the safety of giving CAR T-cell therapy to people with certain B-cell leukemias and lymphomas. In CAR T-cell therapy, T cells taken from a person with cancer are genetically modified to recognize certain molecules on cancer cells, then grown in a lab, and infused back into the patient. The CAR T-cell therapy used in this study recognizes two molecules found only on B cells and some plasma cells.


MRI-Guided Ultrasound Therapy for Prostate Cancer

In this pilot study, people with early prostate cancer will undergo treatment with MRI-guided ultrasound therapy. The ultrasound unit is inserted into the urethra and uses heat to destroy the cancer in the prostate. Doctors want to see if this type of therapy is effective for cancer that hasn’t spread beyond the prostate.