Mpox Vaccine Is Safe and Generates a Robust Antibody Response in Adolescents

National Institute of Allergy and Infectious Diseases sent this bulletin at 10/16/2024 04:38 PM EDT

Wednesday, October 16, 2024

Mpox Vaccine Is Safe and Generates a Robust Antibody Response in Adolescents

Small spheres and oblong shapes, all similar in size, distributed across irregular matter.

Colorized transmission electron micrograph of mpox virus particles (light green) found within VERO E6 cells (teal). The virus particles are in various stages of maturity, which accounts for differences in shape. Captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID

A NIAID-sponsored clinical trial of an mpox vaccine in adolescents found it was safe and generated an antibody response equivalent to that seen in adults, according to interim study results presented at the IDWeek2024 conference in Los Angeles. Adolescents are among the population groups affected by mpox in the current Clade I outbreak. The authors underscored the need to evaluate the vaccine in younger children to extend the evidence base to all people affected by mpox.

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