COVID-19 mRNA Revaccination Is Safe After Allergic Reaction to First Dose, NIAID Trial Finds

National Institute of Allergy and Infectious Diseases sent this bulletin at 03/27/2024 09:00 AM EDT

Wednesday, March 27, 2024

COVID-19 mRNA Revaccination Is Safe After Allergic Reaction to First Dose, NIAID Trial Finds

Gold circles with faint spikes projecting from them on a dark background

Transmission electron micrograph of SARS-CoV-2 virus particles (colorized gold) isolated from a patient sample. Image captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID

A small NIAID clinical trial has found that receiving second and booster doses of a COVID-19 mRNA vaccine under medical supervision was safe for people who reported a systemic allergic reaction to their first dose. After revaccination, 12.5% of study participants had a systemic allergic reaction, while 62.5% had a non-allergic reaction that mimics anaphylaxis and is called Immunization Stress-Related Response (ISRR). These findings highlight the opportunity to assess and manage pre-vaccination anxiety to reduce ISRR. The results are published in the Journal of Allergy and Clinical Immunology.

National Institute of Allergy and Infectious Diseases | National Institutes of Health

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