COVID-19 News: NIAID Trial Tests Strategy to Augment Response to COVID-19 Vaccines in Transplant Recipients

National Institute of Allergy and Infectious Diseases sent this bulletin at 01/31/2022 09:33 AM EST

Monday, January 31, 2022

NIAID Trial Tests Strategy to Augment Response to COVID-19 Vaccines in Transplant Recipients

SEM image of cell infected with SARS-CoV-2

Colorized scanning electron micrograph of a cell (purple) infected with a variant strain of SARS-CoV-2 virus particles (pink), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID

A new NIAID-funded clinical trial is testing whether temporarily reducing immunosuppressive medication taken during the days before and after an additional dose of an mRNA COVID-19 vaccine safely allows for better antibody responses to vaccination in kidney and liver transplant recipients. The study team is enrolling people for whom two to four doses of a COVID-19 mRNA vaccine did not elicit a detectable antibody response. The trial is called COVID Protection After Transplant‒Immunosuppression Reduction, or CPAT-ISR.

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