Guideline SynthesisGuideline SummariesAmerican College of Radiology
Withdrawn Guideline SummariesThe guideline summaries listed below have been withdrawn from the NGC Web site because they no longer meet the NGC Inclusion Criteria. See the Guideline Summaries Archive for a complete list of summaries that have been withdrawn from NGC. American College of Cardiology Foundation
California Diabetes Program
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G-I-N NA Webinar Series: USPSTF Methods for Making Recommendations for Diverse Populations:
When: May 30, 2017 12:30PM ET (11:30PM CT; 10:30AM MT; 9:30AM PT)
Register: https://goo.gl/OM47xy
The U.S. Preventive Services Task Force (USPSTF) makes evidence-based recommendations on clinical preventive services for primary care clinicians and their patients. The Evidence-based Practice Centers (EPCs) support the USPSTF with systematic reviews that are used as the basis for the recommendations. Hear what one EPC and the USPSTF have done to improve recommendations for diverse populations.
Speakers:
Kirsten Bibbins-Domingo, MD, PhD, Professor of Medicine, UCSF and Immediate Past Chair, USPSTF
Jennifer S. Lin, MD, MCR, Director, Kaiser Permanente Research Affiliates EPC
Michelle Eder, PhD, Co-Director, USPSTF Scientific Resource Center
Objectives: By the end of the webinar you will be able to:
For more information contact: Mary Nix at MaryNix@ahrq.hhs.gov
May 16, 2017: Canagliflozin (Invokana, Invokamet): Based on new data from two large clinical trials, the FDA has concluded that the type 2 diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) causes an increased risk of leg and foot amputations. FDA is requiring new warnings, including the most prominent Boxed Warning, to be added to the canagliflozin drug labels to describe this risk.
Final results from two clinical trials – the CANVAS (Canagliflozin Cardiovascular Assessment Study) and CANVAS-R (A Study of the Effects of Canagliflozin on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus) – showed that leg and foot amputations occurred about twice as often in patients treated with canagliflozin compared to patients treated with placebo, which is an inactive treatment. Amputations of the toe and middle of the foot were the most common; however, amputations involving the leg, below and above the knee, also occurred. Some patients had more than one amputation, some involving both limbs.
The Division of Health IT recently released two Funding Opportunity Announcements as part of AHRQ's Patient-Centered Outcomes Research (PCOR) Clinical Decision Support (CDS) Initiative to accelerate evidence into practice through CDS.
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