NGC Update Service: May 29, 2017


May 29, 2017

New This Week

Guideline Synthesis

Guideline Summaries

American College of Radiology

Withdrawn Guideline Summaries

The guideline summaries listed below have been withdrawn from the NGC Web site because they no longer meet the NGC Inclusion Criteria. See the Guideline Summaries Archive for a complete list of summaries that have been withdrawn from NGC.

American College of Cardiology Foundation

  • 2013 ACCF/AHA guideline for the management of heart failure. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.

California Diabetes Program

  • Basic guidelines for diabetes care.


Conference News

G-I-N NA Webinar Series: USPSTF Methods for Making Recommendations for Diverse Populations:

When: May 30, 2017 12:30PM ET (11:30PM CT; 10:30AM MT; 9:30AM PT)


The U.S. Preventive Services Task Force (USPSTF) makes evidence-based recommendations on clinical preventive services for primary care clinicians and their patients. The Evidence-based Practice Centers (EPCs) support the USPSTF with systematic reviews that are used as the basis for the recommendations. Hear what one EPC and the USPSTF have done to improve recommendations for diverse populations.

Kirsten Bibbins-Domingo, MD, PhD, Professor of Medicine, UCSF and Immediate Past Chair, USPSTF
Jennifer S. Lin, MD, MCR, Director, Kaiser Permanente Research Affiliates EPC
Michelle Eder, PhD, Co-Director, USPSTF Scientific Resource Center

Objectives: By the end of the webinar you will be able to:

  1. State methods of synthesizing evidence on subpopulations.
  2. Apply evidence on diverse populations to the development of recommendations on clinical preventive services.

For more information contact: Mary Nix at

U.S. FDA Advisory

May 16, 2017: Canagliflozin (Invokana, Invokamet): Based on new data from two large clinical trials, the FDA has concluded that the type 2 diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) causes an increased risk of leg and foot amputations. FDA is requiring new warnings, including the most prominent Boxed Warning, to be added to the canagliflozin drug labels to describe this risk.

Final results from two clinical trials – the CANVAS (Canagliflozin Cardiovascular Assessment Study) and CANVAS-R (A Study of the Effects of Canagliflozin on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus) – showed that leg and foot amputations occurred about twice as often in patients treated with canagliflozin compared to patients treated with placebo, which is an inactive treatment. Amputations of the toe and middle of the foot were the most common; however, amputations involving the leg, below and above the knee, also occurred. Some patients had more than one amputation, some involving both limbs.

AHRQ Announces Grant Opportunities to Implement Evidence-Based Findings into CDS

The Division of Health IT recently released two Funding Opportunity Announcements as part of AHRQ's Patient-Centered Outcomes Research (PCOR) Clinical Decision Support (CDS) Initiative to accelerate evidence into practice through CDS.

Health Awareness Topics: May 2017

How to Participate

Submit Guidelines: Visit our Submit Guidelines page for information on how to submit your organization's guidelines.

Suggest a Guideline for Possible Inclusion: Submit your suggestions for evidence-based clinical practice guidelines that you would like to see included in NGC.

NGC's Sister Resource

Look for Quality Measures in AHRQ's National Quality Measures Clearinghouse (NQMC).