The endocannabinoid system (ECS) is a cell signaling system made up of receptors, enzymes and endocannabinoids that helps regulate your body functions, like mood, appetite and pain perception. Think of it like a set of locks that use keys to help your body stay balanced: When your body experiences stress, it signals the enzymes to make special keys (endocannabinoids) that fit into the locks (cannabinoid receptors) in the ECS, blocking stress signals. When the locks have their keys, your body works to balance itself — a process called homeostasis.
The process illustrated above occurs in the brain.

When a patient consumes cannabis, it interacts with the ECS. Cannabis contains compounds called phytocannabinoids, which attach themselves to those same receptors and act as extra keys. If you have questions about how cannabis affects the endocannabinoid system, we encourage you to talk to your doctor.
*Researchers are actively studying the ECS to learn more about its structure and function.
The way patients purchase medical marijuana in Oklahoma will change this summer — here’s how and why:
On June 1, 2025, House Bill 3361 will go into effect. The bill requires all medical marijuana and medical marijuana products, except concentrates, to be sold in pre-packaged quantities between 0.5 grams and 3 ounces.
We know there will be a lot of questions from both patients and businesses, so OMMA created a dedicated webpage to provide information, answer FAQs and give updates as they become available. Visit it in the link below.
Oklahoma’s legislative session began Feb. 3, and until the end of May, lawmakers will consider thousands of bills, some of which are relevant to medical marijuana businesses and patients.
For your convenience, OMMA has a dedicated webpage to provide you with legislative updates during session. Visit omma.ok.gov/legislation to see and track bills related to medical marijuana in Oklahoma. Please note this resource is for informational purposes only — it is not an indication that OMMA supports or opposes any legislation.
In the graphic below, you will find some of the important deadlines for the legislative process. Now is the time to reach out to your legislator and share your story and experience regarding bills that are important to you. It’s still very early in the legislative process.

During the last two weeks of January, OMMA participated in budget hearings with state lawmakers ahead of Oklahoma’s legislative session. You can watch the recordings of the budget hearings in the links below. You can also review our FY 2026 Budget Performance Review and our FY 2026 Budget Hearing Presentation.
On Jan. 31, OMMA completed and shared with licensees an Agency Rule Report after a public comment period that ended with a public hearing at the state Capitol. As part of the rulemaking process, the rule report was submitted to Gov. Kevin Stitt and the Legislature for consideration during legislative session. Pending approval from the Governor, these rules will take effect later in 2025.

|