Please share the following information with staff and colleagues.
Moderna recently revised the package insert for its mRNA RSV vaccine (mResvia) providing new instructions on thawing frozen vaccine in either a refrigerator or at room temperature before administration. Most of the current thawing intervals are longer than previously recommended.
Cartons with either one or two pre-filled syringes may be thawed in one of two ways:
- Thaw between 2 to 8°C (36 to 46°F) for 100 minutes. Let syringe stand at room temperature for 10 to 20 minutes before administering, or
- Thaw between 15 to 25°C (59 to 77°F) for 40 minutes. At that point, mResvia is ready to be administered.
Cartons with 10 pre-filled syringes may be thawed in one of two ways:
- Thaw between 2 to 8°C (36 to 46°F) for 160 minutes. Let syringe stand at room temperature for between 10 and 20 minutes before administering, or
- Thaw between 15 to 25°C (59 to 77°F) for 80 minutes. At that point, mResvia is ready to be administered.
After thawing, do not refreeze. The mResvia syringes may be stored in a refrigerator for up to 90 days before use. The mResvia vaccine may be stored at room temperature for up to 24 hours after removal from refrigerated conditions. Discard if not used within this time. Syringes should not be returned to the refrigerator after standing at room temperature. See the mResvia package insert for additional instructions.
As a reminder, Immunize.org offers convenient access to package inserts for all FDA-licensed or authorized vaccines at its Official Guidance web page.
Thank you for all you do!
Oakland County Health and Human Services, Immunization Action Plan
