MMWR Measles, Mumps, Rubella Vaccine (PRIORIX): Recommendations of the Advisory Committee on Immunization Practices

Oakland County, Michigan sent this bulletin at 11/22/2022 07:46 AM EST

This email is being sent to VFC, Non-VFC and Covid-19 Providers in Oakland County, Michigan by the Oakland County Health Division (OCHD) Immunization Action Plan (IAP)

mdhhs

Good morning immunization partners,

Please share the following information with staff and colleagues.

On November 18, 2022, The Centers for Disease Control and Prevention (CDC) published an MMWR article titled Measles, Mumps, Rubella Vaccine (PRIORIX): Recommendations of the Advisory Committee on Immunization Practices.

Since 1978, M-M-R II has been the only measles, mumps, and rubella (MMR) combination vaccine used in the United States. In June 2022, the Food and Drug Administration licensed an additional MMR vaccine, PRIORIX. On June 23, 2022, the Advisory Committee on Immunization Practices (ACIP) recommended PRIORIX as an additional option to prevent measles, mumps, and rubella (MMR) according to existing vaccine recommendations and off-label uses.

Given the similarities in potency and vaccine components, and evidence for similar safety and immunogenicity, as well as stakeholder support, PRIORIX and M-M-R II are considered fully interchangeable, including for all off-label recommended uses. Either vaccine may be administered in any situation in which an MMR virus–containing vaccine is indicated. Two interchangeable vaccines from different manufacturers will help safeguard vaccine supply in the United States to maintain measles and rubella elimination and mitigate mumps cases and outbreaks.

PRIORIX is supplied as a single-dose vial of lyophilized antigen to be reconstituted with the accompanying prefilled syringe of sterile water diluent. A single dose after reconstitution is approximately 0.5 mL. PRIORIX is formulated without preservatives and is administered as subcutaneous injection (the same as M-M-R II).

For routine vaccination, 2 doses are recommended, the first at age 12–15 months, and the second at age 4–6 years. For catch-up vaccination of previously unvaccinated children and adolescents, 2 doses should be administered ≥4 weeks apart. Before international travel, infants aged 6–11 months should receive a single dose. Travelers aged ≥12 months who have not received 2 doses of MMR should receive 2 doses separated by ≥28 days.

Stay tuned for more educational guidance from MDHHS. For additional clinical guidance regarding vaccinating during a measles/mumps outbreak, administering concomitantly, and precautions and contraindications review the full MMWR here.

Thank you for all you do to protect Michiganders from vaccine preventable diseases.

Oakland County Health Division, Immunization Action Plan