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S-Adenosyl-L-methionine, also called SAMe or
SAM-e, is a chemical found naturally in the body. SAMe is sold in the United
States as a dietary supplement.
Early
research showed SAMe is involved in a variety of body functions, especially in
the brain and the liver. These findings prompted researchers to investigate the
possible value of SAMe in the treatment of mental illnesses and liver diseases.
During clinical trials in people with depression, some study participants who
also had osteoarthritis reported that their joint symptoms improved when they
were taking SAMe.
This
fact sheet provides basic information about SAMe, summarizes scientific
research on safety and effectiveness, and suggests sources for additional
information. See http://1.usa.gov/1RNwBVg.
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